Brezski, R. J. : rechercher sur Z-Library

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1

A Novel Bispecific Antibody Targeting EGFR and cMet that is Effective Against EGFR Inhibitor- Resistant Lung Tumors

Moores, S. L., Chiu, M. >, Bushey, B. S., Chevalier, K., Luistro, L., Dorn, K., Brezski, R. J., Haytko, P., Kelly, T., Wu, S.-J., Martin, P. L., Neijssen, J., Parren, P. W., Schuurman, J., Attar, R. M

Journal:

Cancer Research

Année:

2016

Langue:

english

Fichier:

PDF, 2.04 MB

english, 2016

2

Tonic B cell antigen receptor signals supply an NF-κB substrate for prosurvival BLyS signaling

Stadanlick, Jason E, Kaileh, Mary, Karnell, Fredrick G, Scholz, Jean L, Miller, Juli P, Quinn III, William J, Brezski, Randall J, Treml, Laura S, Jordan, Kimberly A, Monroe, John G

Journal:

Nature Immunology

Année:

2008

Langue:

english

Fichier:

PDF, 735 KB

english, 2008

3

Avidity confers FcγR binding and immune effector function to aglycosylated immunoglobulin G1

Thomas C. Nesspor, T. Shantha Raju, Chen -Ni Chin, Omid Vafa, Randall J. Brezski

Journal:

Journal of Molecular Recognition

Année:

2012

Langue:

english

Fichier:

PDF, 1.38 MB

english, 2012

4

A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function andin vivoefficacy

Xuejun Fan, Randall J Brezski, Ming Fa, Hui Deng, Allison Oberholtzer, Anneliese Gonzalez, William P Dubinsky, William R Strohl, Robert E Jordan, Ningyan Zhang, Zhiqiang An

Journal:

Breast Cancer Research

Année:

2012

Langue:

english

Fichier:

PDF, 1.59 MB

english, 2012

5

An engineered Fc variant of an IgG eliminates all immune effector functions via structural perturbations

Vafa, Omid, Gilliland, Gary L., Brezski, Randall J., Strake, Brandy, Wilkinson, Teresa, Lacy, Eilyn R., Scallon, Bernard, Teplyakov, Alexey, Malia, Thomas J., Strohl, William R.

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 2.72 MB

english, 2014

6

Structure and specificity of an antibody targeting a proteolytically cleaved IgG hinge

Malia, Thomas J., Teplyakov, Alexey, Brezski, Randall J., Luo, Jinquan, Kinder, Michelle, Sweet, Raymond W., Almagro, Juan C., Jordan, Robert E., Gilliland, Gary L.

Journal:

Proteins: Structure, Function, and Bioinformatics

Année:

2014

Langue:

english

Fichier:

PDF, 653 KB

english, 2014

7

Cleavage of IgGs by proteases associated with invasive diseases

Brezski, Randall J., Jordan, Robert E.

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 325 KB

english, 2010

8

A Novel Therapeutic Strategy to Rescue the Immune Effector Function of Proteolytically Inactivated Cancer Therapeutic Antibodies

Fan, X., Brezski, R. J., Deng, H., Dhupkar, P. M., Shi, Y., Gonzalez, A., Zhang, S., Rycyzyn, M., Strohl, W. R., Jordan, R. E., Zhang, N., An, Z.

Journal:

Molecular Cancer Therapeutics

Année:

2015

Langue:

english

Fichier:

PDF, 1.06 MB

english, 2015

9

Tumor-Associated Macrophages Promote Invasion while Retaining Fc-Dependent Anti-Tumor Function

Grugan, K. D., McCabe, F. L., Kinder, M., Greenplate, A. R., Harman, B. C., Ekert, J. E., van Rooijen, N., Anderson, G. M., Nemeth, J. A., Strohl, W. R., Jordan, R. E., Brezski, R. J.

Journal:

The Journal of Immunology

Année:

2012

Langue:

english

Fichier:

PDF, 1.57 MB

english, 2012

10

A monoclonal antibody against hinge-cleaved IgG restores effector function to proteolytically-inactivated IgGs in vitro and in vivo

Brezski, Randall J, Kinder, Michelle, Grugan, Katharine D, Soring, Keri L, Carton, Jill, Greenplate, Allison R, Petley, Theodore, Capaldi, Dorie, Brosnan, Kerry, Emmell, Eva, Watson, Sharon, Jordan, R

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 1.32 MB

english, 2014

11

B Cell Antigen Receptor-Induced Rac1 Activation and Rac1-Dependent Spreading Are Impaired in Transitional Immature B Cells Due to Levels of Membrane Cholesterol

Brezski, R. J., Monroe, J. G.

Journal:

The Journal of Immunology

Année:

2007

Langue:

english

Fichier:

PDF, 1.14 MB

english, 2007

12

Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge

Brezski, R. J., Vafa, O., Petrone, D., Tam, S. H., Powers, G., Ryan, M. H., Luongo, J. L., Oberholtzer, A., Knight, D. M., Jordan, R. E.

Journal:

Proceedings of the National Academy of Sciences

Année:

2009

Langue:

english

Fichier:

PDF, 514 KB

english, 2009

13

Trastuzumab Triggers Phagocytic Killing of High HER2 Cancer Cells In Vitro and In Vivo by Interaction with Fc Receptors on Macrophages

Shi, Y., Fan, X., Deng, H., Brezski, R. J., Rycyzyn, M., Jordan, R. E., Strohl, W. R., Zou, Q., Zhang, N., An, Z.

Journal:

The Journal of Immunology

Année:

2015

Langue:

english

Fichier:

PDF, 1.34 MB

english, 2015

14

The in vitro resistance of IgG2 to proteolytic attack concurs with a comparative paucity of autoantibodies against peptide analogs of the IgG2 hinge

Brezski, Randall J., Oberholtzer, Allison, Strake, Brandy, Jordan, Robert E.

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 2.71 MB

english, 2011

15

An Fc engineering approach that modulates antibody-dependent cytokine release without altering cell-killing functions

Kinder, Michelle, Greenplate, Allison R, Strohl, William R, Jordan, Robert E, Brezski, Randall J

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 1.88 MB

english, 2015

16

Human Anti-IgG1 Hinge Autoantibodies Reconstitute the Effector Functions of Proteolytically Inactivated IgGs

Brezski, R. J., Luongo, J. L., Petrone, D., Ryan, M. H., Zhong, D., Tam, S. H., Schmidt, A. P., Kruszynski, M., Whitaker, B. P., Knight, D. M., Jordan, R. E.

Journal:

The Journal of Immunology

Année:

2008

Langue:

english

Fichier:

PDF, 774 KB

english, 2008

17

Membrane Cholesterol Content Accounts for Developmental Differences in Surface B Cell Receptor Compartmentalization and Signaling

Karnell, Fredrick G., Brezski, Randall J., King, Leslie B., Silverman, Michael A., Monroe, John G.

Journal:

Journal of Biological Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 905 KB

english, 2005

18

Dysfunctional antibodies in the tumor microenvironment associate with impaired anticancer immunity

N. Zhang, H. Deng, X. Fan, A. Gonzalez, S. Zhang, R. J. Brezski, B. Choi, M. Rycyzyn, W. R. Strohl, R. E. Jordan, Z. An

Année:

2015

Langue:

english

Fichier:

PDF, 59 KB

english, 2015

19

9th Annual European Antibody Congress, November 11–13, 2013, Geneva, Switzerland

Reichert, Janice M, Beck, Alain, Lugovskoy, Alexey A, Wurch, Thierry, Coats, Steven, Brezski, Randall J

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 618 KB

english, 2014

20

Proteolytic Cleavage and Loss of Function of Biologic Agents That Neutralize Tumor Necrosis Factor in the Mucosa of Patients With Inflammatory Bowel Disease

Biancheri, Paolo, Brezski, Randall J., Di Sabatino, Antonio, Greenplate, Allison R., Soring, Keri L., Corazza, Gino R., Kok, Klaartje B., Rovedatti, Laura, Vossenkämper, Anna, Ahmad, Nadja, Snoek, Sus

Journal:

Gastroenterology

Année:

2015

Langue:

english

Fichier:

PDF, 1.95 MB

english, 2015

21

Tendances séculaires de la croissance économique

Review by: A. Brezski and A. Brzeski

Journal:

Annales Histoire Sciences Sociales

Année:

1965

Fichier:

PDF, 614 KB

1965

22

A peptide immunization approach to counteract a Staphylococcus aureus protease defense against host immunity

Jordan, Robert E., Fernandez, Jeffrey, Brezski, Randall J., Greenplate, Allison R., Knight, David M., Raju, T. Shantha, Lynch, A. Simon

Journal:

Immunology Letters

Année:

2016

Langue:

english

Fichier:

PDF, 1.96 MB

english, 2016

23

Immunoglobulin isotype knowledge and application to Fc engineering

Brezski, Randall J, Georgiou, George

Journal:

Current Opinion in Immunology

Année:

2016

Fichier:

PDF, 946 KB

2016

24

Immunoglobulin isotype knowledge and application to Fc engineering

Brezski, Randall J, Georgiou, George

Journal:

Current Opinion in Immunology

Année:

2016

Langue:

english

Fichier:

PDF, 946 KB

english, 2016

25

FcRn binding is not sufficient for achieving systemic therapeutic levels of immunoglobulin G after oral delivery of enteric-coated capsules in cynomolgus macaques

Muzammil, Salman, Mabus, John R., Cooper, Philip R., Brezski, Randall J., Bement, Courtney B., Perkinson, Rob, Huebert, Norman D., Thompson, Suzanne, Levine, Dalia, Kliwinski, Connie, Bradley, Dino, H

Journal:

Pharmacology Research & Perspectives

Année:

2016

Langue:

english

Fichier:

PDF, 1.03 MB

english, 2016

26

IgG Fc engineering to modulate antibody effector functions

Wang, Xinhua, Mathieu, Mary, Brezski, Randall J.

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 1.41 MB

english, 2017

27

Molecular characterization of human anti-hinge antibodies derived from single cell cloning of normal human B cells

Huang, Tao, Mathieu, Mary, Lee, Sophia, Wang, Xinhua, Kee, Yee Seir, Bevers, Jack J, Ciferri, Claudio, Estavez, Alberto, Wong, Manda, Chiang, Nancy Y, Nakamura, Gerald, Brezski, Randall J

Journal:

Journal of Biological Chemistry

Année:

2017

Langue:

english

Fichier:

PDF, 1.45 MB

english, 2017

28

Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies || Novel Generation of Antibody-Based Therapeutics

Brezski, Randall J.

Année:

2015

Fichier:

PDF, 1.68 MB

2015

29

Domain-Specific Antibodies Reveal Differences in the Membrane Topologies of Apolipoprotein L1 in Serum and Podocytes

Gupta, Nidhi, Wang, Xinhua, Wen, Xiaohui, Moran, Paul, Paluch, Maciej, Hass, Philip E., Heidersbach, Amy, Haley, Benjamin, Kirchhofer, Daniel, Brezski, Randall J., Peterson, Andrew S., Scales, Suzie J

Journal:

Journal of the American Society of Nephrology

Année:

2020

Fichier:

PDF, 1.46 MB

2020